USMLEPrepUSMLEPrep

Histology atlas

Free histology slides for Step 1 and Shelf exams. Labeled normal tissue and pathology across every organ system — kidney, liver, cardiac muscle, neural tissue and more. H&E, PAS, trichrome, silver stains.

Cardiovascular

Atherosclerosis — fibrous cap + lipid core — Intima with atheroma, H&E stain
Pathologic·Artery (aorta/coronary)
Atherosclerosis — fibrous cap + lipid core
Stain: H&E
Cardiac muscle — intercalated discs — Cardiac muscle, H&E stain
Normal·Myocardium
Cardiac muscle — intercalated discs
Stain: H&E

Endocrine

Adrenal cortex — GFR zones — Adrenal cortex, H&E stain
Normal·Adrenal gland
Adrenal cortex — GFR zones
Stain: H&E
Anterior pituitary — acidophils, basophils, chromophobes — Pars distalis, H&E stain
Normal·Pituitary gland
Anterior pituitary — acidophils, basophils, chromophobes
Stain: H&E
Parathyroid — chief + oxyphil cells — Endocrine parenchyma, H&E stain
Normal·Parathyroid gland
Parathyroid — chief + oxyphil cells
Stain: H&E
Thyroid — follicles + colloid — Follicular epithelium, H&E stain
Normal·Thyroid
Thyroid — follicles + colloid
Stain: H&E

GI

Esophagus — non-keratinized stratified squamous epithelium — Stratified squamous epithelium, non-keratinized, H&E stain
Normal·Esophagus
Esophagus — non-keratinized stratified squamous epithelium
Stain: H&E
Liver — classic hepatic lobule — Hepatic parenchyma, H&E stain
Normal·Liver
Liver — classic hepatic lobule
Stain: H&E
Pancreas — exocrine acini + endocrine islet — Mixed exo/endocrine, H&E stain
Normal·Pancreas
Pancreas — exocrine acini + endocrine islet
Stain: H&E
Simple columnar epithelium — small intestine villus — Simple columnar with microvilli, H&E stain
Normal·Small intestine
Simple columnar epithelium — small intestine villus
Stain: H&E
Stomach — fundic mucosa with parietal + chief cells — Gastric mucosa, H&E stain
Normal·Stomach
Stomach — fundic mucosa with parietal + chief cells
Stain: H&E
Submandibular salivary gland — mixed acini + serous demilunes — Mixed exocrine acini, H&E stain
Normal·Salivary gland
Submandibular salivary gland — mixed acini + serous demilunes
Stain: H&E

Hematology/Immunology

Lymph node — cortex / paracortex / medulla — Secondary lymphoid, H&E stain
Normal·Lymph node
Lymph node — cortex / paracortex / medulla
Stain: H&E
Peripheral smear — AML with Auer rods — Blood smear, Wright-Giemsa stain
Pathologic·Peripheral blood
Peripheral smear — AML with Auer rods
Stain: Wright-Giemsa
Spleen — white pulp + red pulp — Lymphoreticular, H&E stain
Normal·Spleen
Spleen — white pulp + red pulp
Stain: H&E

Integumentary

Skin — sebaceous glands inserting into hair shaft — Pilosebaceous unit, H&E stain
Normal·Skin (scalp)
Skin — sebaceous glands inserting into hair shaft
Stain: H&E
Stratified squamous epithelium (keratinized) — thin skin — Stratified squamous epithelium, keratinized, H&E stain
Normal·Skin
Stratified squamous epithelium (keratinized) — thin skin
Stain: H&E

Musculoskeletal

Compact bone — osteon (Haversian system) — Lamellar bone, H&E stain
Normal·Long bone diaphysis
Compact bone — osteon (Haversian system)
Stain: H&E
Hyaline cartilage — tracheal ring — Hyaline cartilage, H&E stain
Normal·Trachea
Hyaline cartilage — tracheal ring
Stain: H&E
Skeletal muscle — longitudinal section — Skeletal muscle, H&E stain
Normal·Skeletal muscle
Skeletal muscle — longitudinal section
Stain: H&E

Neurology

Cerebellum — Purkinje cell layer — Cerebellar cortex (molecular, Purkinje, granular layers), H&E stain
Normal·Cerebellum
Cerebellum — Purkinje cell layer
Stain: H&E
Cerebral cortex — pyramidal neurons — CNS — six-layered neocortex, H&E stain
Normal·Cerebrum
Cerebral cortex — pyramidal neurons
Stain: H&E
Peripheral nerve — cross section — Mixed nerve fascicles, H&E stain
Normal·Peripheral nerve
Peripheral nerve — cross section
Stain: H&E
Spinal cord — cross section with gray matter horns — CNS — gray + white matter, H&E stain
Normal·Spinal cord
Spinal cord — cross section with gray matter horns
Stain: H&E

Pathology

Acute MI — coagulative necrosis of cardiomyocytes — Infarcted cardiac muscle, H&E stain
Pathologic·Heart (myocardium)
Acute MI — coagulative necrosis of cardiomyocytes
Stain: H&E
Adenocarcinoma — colon — Glandular, H&E stain
Pathologic·Colon
Adenocarcinoma — colon
Stain: H&E
Cervical intraepithelial neoplasia (CIN 2 / HSIL) — Squamous epithelium with HPV-driven dysplasia, H&E stain
Pathologic·Cervix
Cervical intraepithelial neoplasia (CIN 2 / HSIL)
Stain: H&E
Comedo DCIS — high-grade ductal carcinoma in situ — Mammary duct with neoplastic epithelium, H&E stain
Pathologic·Breast
Comedo DCIS — high-grade ductal carcinoma in situ
Stain: H&E
Crescentic glomerulonephritis (RPGN) — Renal cortex — glomerulus, PAS stain
Pathologic·Kidney
Crescentic glomerulonephritis (RPGN)
Stain: PAS
Granulomatous inflammation — non-caseating (sarcoid pattern) — Granuloma, H&E stain
Pathologic
Granulomatous inflammation — non-caseating (sarcoid pattern)
Stain: H&E
Liver cirrhosis — regenerative nodules + bridging fibrosis (Trichrome) — Hepatic parenchyma with fibrosis, Masson trichrome stain
Pathologic·Liver
Liver cirrhosis — regenerative nodules + bridging fibrosis (Trichrome)
Stain: Masson trichrome
Squamous cell carcinoma with keratin pearls — Squamous epithelium, H&E stain
Pathologic
Squamous cell carcinoma with keratin pearls
Stain: H&E

Renal/Urinary

Renal cortex — glomerulus + tubules — Renal cortex, H&E stain
Normal·Kidney
Renal cortex — glomerulus + tubules
Stain: H&E
Smooth muscle — bladder wall (detrusor) — Smooth muscle, H&E stain
Normal·Bladder
Smooth muscle — bladder wall (detrusor)
Stain: H&E
Transitional epithelium (urothelium) — urinary bladder — Transitional epithelium, H&E stain
Normal·Bladder
Transitional epithelium (urothelium) — urinary bladder
Stain: H&E

Reproductive

Corpus luteum — luteinized granulosa + theca cells — Post-ovulatory follicle, H&E stain
Normal·Ovary
Corpus luteum — luteinized granulosa + theca cells
Stain: H&E
Endometrium — secretory phase — Endometrial glands + stroma, H&E stain
Normal·Uterus
Endometrium — secretory phase
Stain: H&E
Ovary — Graafian (mature) follicle — Ovarian cortex with mature follicle, H&E stain
Normal·Ovary
Ovary — Graafian (mature) follicle
Stain: H&E
Placenta — chorionic villi with syncytiotrophoblast — Chorionic villus, H&E stain
Normal·Placenta
Placenta — chorionic villi with syncytiotrophoblast
Stain: H&E
Testis — seminiferous tubules with spermatogenesis — Seminiferous epithelium, H&E stain
Normal·Testis
Testis — seminiferous tubules with spermatogenesis
Stain: H&E

Respiratory

Asthma — airway remodeling + eosinophilic inflammation — Bronchial wall with goblet cell metaplasia, H&E stain
Pathologic·Bronchus
Asthma — airway remodeling + eosinophilic inflammation
Stain: H&E
Lung — alveolar parenchyma — Alveolar, H&E stain
Normal·Lung
Lung — alveolar parenchyma
Stain: H&E
Pseudostratified ciliated columnar epithelium — trachea — Pseudostratified ciliated columnar, H&E stain
Normal·Trachea
Pseudostratified ciliated columnar epithelium — trachea
Stain: H&E

Special Senses

Retina — vertical section showing all layers — Neural retina + RPE, H&E stain
Normal·Eye
Retina — vertical section showing all layers
Stain: H&E

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