Pathologic·Pathology·Breast
Comedo DCIS — high-grade ductal carcinoma in situ
Stain: H&E·Magnification: 10x·Tissue: Mammary duct with neoplastic epithelium·3 labeled regions
Wikimedia Commons · File:Comedo_DCIS.jpg · https://commons.wikimedia.org/wiki/File:Comedo_DCIS.jpg (CC-licensed)
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Malignant cells fill duct lumen with central comedonecrosis (eosinophilic debris ± dystrophic calcification on mammography). High-grade DCIS — likely to progress to invasive ductal carcinoma. Pleomorphic nuclei, brisk mitoses, no stromal invasion (in situ).
Labeled regions (3)
- 1Central comedonecrosis
Eosinophilic necrotic debris in duct center — pathognomonic feature. Calcifies → microcalcifications on mammography.
- 2Pleomorphic neoplastic cells
Large nuclei, irregular contours, prominent nucleoli — high-grade cytology lining the duct.
- 3Intact ductal basement membrane
No stromal invasion = "in situ". Invasive ductal carcinoma defined by crossing this boundary.
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