Normal·Reproductive·Ovary
Ovary — Graafian (mature) follicle
Stain: H&E·Magnification: 10x·Tissue: Ovarian cortex with mature follicle·4 labeled regions
Wikimedia Commons · File:Graafian_Follicle,_Human_Ovary_(3595817584).jpg · https://commons.wikimedia.org/wiki/File:Graafian_Follicle,_Human_Ovary_(3595817584).jpg (CC-licensed)
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Mature (Graafian) follicle just before ovulation: oocyte suspended in a large antrum, surrounded by cumulus oophorus + corona radiata, walled by granulosa + theca layers.
Labeled regions (4)
- 1Oocyte
Arrested in meiosis II until fertilization. Large eosinophilic cytoplasm with prominent nucleolus (germinal vesicle).
- 2Antrum
Fluid-filled cavity (follicular fluid). Defines the antral / Graafian stages.
- 3Granulosa layer
Stratified epithelial cells producing estrogen (aromatase, FSH-driven). Convert to corpus luteum after ovulation.
- 4Theca interna
Outer wall, vascularized stromal cells; LH-driven androgen production (substrate for granulosa aromatase).
