Pathologic·Pathology·Colon
Adenocarcinoma — colon
Stain: H&E·Magnification: 20x·Tissue: Glandular·4 labeled regions
Wikimedia Commons · File:Micrograph of colorectal carcinoma with dirty necrosis.jpg · https://commons.wikimedia.org/wiki/File:Micrograph_of_colorectal_carcinoma_with_dirty_necrosis.jpg (CC-licensed)
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Malignant glands with cribriform / back-to-back architecture, nuclear atypia, and stromal desmoplasia. Invades through muscularis mucosae.
Labeled regions (4)
- 1Atypical neoplastic glands
Irregular, complex shapes; back-to-back without intervening stroma.
- 2Nuclear pleomorphism
Variable nuclear size + shape; hyperchromasia.
- 3Desmoplastic stroma
Pink dense fibrous reaction to invasion.
- 4Mitotic figure
Abnormal mitoses are a malignancy clue.
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