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Pathologic·Pathology·Colon

Adenocarcinoma — colon

Stain: H&E·Magnification: 20x·Tissue: Glandular·4 labeled regions
Adenocarcinoma — colon histology — Pathology, Colon, H&E
Wikimedia Commons · File:Micrograph of colorectal carcinoma with dirty necrosis.jpg · https://commons.wikimedia.org/wiki/File:Micrograph_of_colorectal_carcinoma_with_dirty_necrosis.jpg (CC-licensed)
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Description

Malignant glands with cribriform / back-to-back architecture, nuclear atypia, and stromal desmoplasia. Invades through muscularis mucosae.

Labeled regions (4)

  1. 1
    Atypical neoplastic glands

    Irregular, complex shapes; back-to-back without intervening stroma.

  2. 2
    Nuclear pleomorphism

    Variable nuclear size + shape; hyperchromasia.

  3. 3
    Desmoplastic stroma

    Pink dense fibrous reaction to invasion.

  4. 4
    Mitotic figure

    Abnormal mitoses are a malignancy clue.

More pathology histology

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Comedo DCIS — high-grade ductal carcinoma in situ
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Liver cirrhosis — regenerative nodules + bridging fibrosis (Trichrome)
Liver cirrhosis — regenerative nodules + bridging fibrosis (Trichrome)
Liver
Cervical intraepithelial neoplasia (CIN 2 / HSIL)
Cervical intraepithelial neoplasia (CIN 2 / HSIL)
Cervix
Acute MI — coagulative necrosis of cardiomyocytes
Acute MI — coagulative necrosis of cardiomyocytes
Heart (myocardium)
Granulomatous inflammation — non-caseating (sarcoid pattern)
Granulomatous inflammation — non-caseating (sarcoid pattern)
Squamous cell carcinoma with keratin pearls
Squamous cell carcinoma with keratin pearls