Pathologic·Pathology·Cervix
Cervical intraepithelial neoplasia (CIN 2 / HSIL)
Stain: H&E·Magnification: 20x·Tissue: Squamous epithelium with HPV-driven dysplasia·3 labeled regions
Wikimedia Commons · File:CIN 2 (HSIL), H&E (7205728262).jpg · https://commons.wikimedia.org/wiki/File:CIN_2_(HSIL),_H%26E_(7205728262).jpg (CC-licensed)
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High-grade squamous intraepithelial lesion: dysplastic cells extend through > lower 1/3 of epithelium with loss of orderly maturation, nuclear pleomorphism, ↑ N:C ratio, and mitotic figures. Driven by high-risk HPV (16/18) E6/E7 → p53/Rb inactivation.
Labeled regions (3)
- 1Dysplastic epithelium (full thickness)
Loss of normal maturation — dark, crowded basaloid cells reach above the lower third. CIN 3 = full thickness.
- 2Increased N:C ratio + pleomorphism
Nuclei are large, irregular, hyperchromatic. Look for mitotic figures in upper layers.
- 3Intact basement membrane
Defines "in situ" — no invasion. Invasion through BM = squamous cell carcinoma.
More pathology histology
Comedo DCIS — high-grade ductal carcinoma in situ
Breast
Liver cirrhosis — regenerative nodules + bridging fibrosis (Trichrome)
Liver
Acute MI — coagulative necrosis of cardiomyocytes
Heart (myocardium)
Adenocarcinoma — colon
Colon
Granulomatous inflammation — non-caseating (sarcoid pattern)
Squamous cell carcinoma with keratin pearls