Pathologic·Pathology
Granulomatous inflammation — non-caseating (sarcoid pattern)
Stain: H&E·Magnification: 20x·Tissue: Granuloma·4 labeled regions
Wikimedia Commons · File:Granuloma 20x.jpg · https://commons.wikimedia.org/wiki/File:Granuloma_20x.jpg (CC-licensed, sarcoid lymph node)
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Tight aggregates of epithelioid macrophages with multinucleated giant cells, surrounded by lymphocytic rim. NO central caseation — distinguishes from TB / fungal.
Labeled regions (4)
- 1Epithelioid macrophage
Activated macrophage with abundant pink cytoplasm.
- 2Multinucleated giant cell
Fused macrophages; Langhans pattern (horseshoe nuclei) is classic.
- 3Lymphocytic rim
T cells encircle the granuloma; drives the Th1 response.
- 4Absent caseation
Center is pink + cellular, not necrotic — differentiates from TB.
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