Pathologic·Pathology·Liver

Liver cirrhosis — regenerative nodules + bridging fibrosis (Trichrome)

Stain: Masson trichrome·Magnification: 4x·Tissue: Hepatic parenchyma with fibrosis·3 labeled regions

Wikimedia Commons · File:Cirrhosis_of_the_liver_(trichrome_stain)_(5690946257).jpg · https://commons.wikimedia.org/wiki/File:Cirrhosis_of_the_liver_(trichrome_stain)_(5690946257).jpg (CC-licensed)

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Description

End-stage chronic liver injury: parenchyma reorganized into regenerative nodules walled off by blue-staining (collagen, on Trichrome) bridging fibrous septa. Loss of normal lobular architecture → portal hypertension + impaired function.

Labeled regions (3)

1
Regenerative nodule
Round island of hepatocytes that has regrown without normal lobular orientation. Lacks central vein.
2
Bridging fibrosis (blue)
Bands of collagen (stellate cell-derived) connecting portal-portal or portal-central. Trichrome stains collagen blue.
3
Distorted vascular architecture
Intrahepatic shunts across fibrous septa raise portal pressure → varices, ascites, splenomegaly.