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Normal·Hematology/Immunology·Lymph node

Lymph node — cortex / paracortex / medulla

Stain: H&E·Magnification: 10x·Tissue: Secondary lymphoid·4 labeled regions
Lymph node — cortex / paracortex / medulla histology — Hematology/Immunology, Lymph node, H&E
Wikimedia Commons · File:Normal Lymph Node.jpg · https://commons.wikimedia.org/wiki/File:Normal_Lymph_Node.jpg (CC-licensed)
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Description

B-cell follicles (cortex) → T-cell paracortex → plasma-cell-rich medulla. Architecture is the basis for differential dx of lymphoma vs reactive hyperplasia.

Labeled regions (4)

  1. 1
    Cortex with germinal center

    B-cell follicle; active in immune response.

  2. 2
    Paracortex

    T-cell zone; underdeveloped in DiGeorge.

  3. 3
    Medullary cords

    Plasma cells + macrophages.

  4. 4
    Subcapsular sinus

    Receives afferent lymph.

More hematology/immunology histology

Spleen — white pulp + red pulp
Spleen — white pulp + red pulp
Spleen
Peripheral smear — AML with Auer rods
Peripheral smear — AML with Auer rods
Peripheral blood