USMLEPrepUSMLEPrep
Pathologic·Pathology·Kidney

Crescentic glomerulonephritis (RPGN)

Stain: PAS·Magnification: 40x·Tissue: Renal cortex — glomerulus·3 labeled regions
Crescentic glomerulonephritis (RPGN) histology — Pathology, Kidney, PAS
Wikimedia Commons · File:Crescentic glomerulonephritis (2).jpg · https://commons.wikimedia.org/wiki/File:Crescentic_glomerulonephritis_(2).jpg (CC-licensed, MPO-ANCA positive RPGN)
Open the interactive viewer

Sign up free to pan/zoom up to 10×, tap each labeled marker for the structure's description and clinical context, and switch to quiz mode to test yourself on every region.

Create free account

Description

Cellular crescent fills Bowman space, compressing the tuft. Marker of rapidly progressive GN — anti-GBM, ANCA, or immune-complex etiologies.

Labeled regions (3)

  1. 1
    Crescent

    Proliferation of parietal epithelial cells + macrophages in Bowman space.

  2. 2
    Compressed glomerular tuft

    Capillary loops pushed centrally by the crescent.

  3. 3
    Disrupted Bowman capsule

    Outlines of capsule blurred by fibrin/cellular reaction.

More pathology histology

Comedo DCIS — high-grade ductal carcinoma in situ
Comedo DCIS — high-grade ductal carcinoma in situ
Breast
Liver cirrhosis — regenerative nodules + bridging fibrosis (Trichrome)
Liver cirrhosis — regenerative nodules + bridging fibrosis (Trichrome)
Liver
Cervical intraepithelial neoplasia (CIN 2 / HSIL)
Cervical intraepithelial neoplasia (CIN 2 / HSIL)
Cervix
Acute MI — coagulative necrosis of cardiomyocytes
Acute MI — coagulative necrosis of cardiomyocytes
Heart (myocardium)
Adenocarcinoma — colon
Adenocarcinoma — colon
Colon
Granulomatous inflammation — non-caseating (sarcoid pattern)
Granulomatous inflammation — non-caseating (sarcoid pattern)