Pathologic·Pathology·Kidney
Crescentic glomerulonephritis (RPGN)
Stain: PAS·Magnification: 40x·Tissue: Renal cortex — glomerulus·3 labeled regions
Wikimedia Commons · File:Crescentic glomerulonephritis (2).jpg · https://commons.wikimedia.org/wiki/File:Crescentic_glomerulonephritis_(2).jpg (CC-licensed, MPO-ANCA positive RPGN)
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Cellular crescent fills Bowman space, compressing the tuft. Marker of rapidly progressive GN — anti-GBM, ANCA, or immune-complex etiologies.
Labeled regions (3)
- 1Crescent
Proliferation of parietal epithelial cells + macrophages in Bowman space.
- 2Compressed glomerular tuft
Capillary loops pushed centrally by the crescent.
- 3Disrupted Bowman capsule
Outlines of capsule blurred by fibrin/cellular reaction.
More pathology histology
Comedo DCIS — high-grade ductal carcinoma in situ
Breast
Liver cirrhosis — regenerative nodules + bridging fibrosis (Trichrome)
Liver
Cervical intraepithelial neoplasia (CIN 2 / HSIL)
Cervix
Acute MI — coagulative necrosis of cardiomyocytes
Heart (myocardium)
Adenocarcinoma — colon
Colon
Granulomatous inflammation — non-caseating (sarcoid pattern)