Pathologic·Pathology
Squamous cell carcinoma with keratin pearls
Stain: H&E·Magnification: 20x·Tissue: Squamous epithelium·3 labeled regions
Wikimedia Commons · File:Oral cancer (1) squamous cell carcinoma histopathology.jpg · https://commons.wikimedia.org/wiki/File:Oral_cancer_(1)_squamous_cell_carcinoma_histopathology.jpg (CC-licensed)
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Nests of malignant squamous cells with abundant pink cytoplasm + intercellular bridges. Keratin pearls (concentric layers of keratin) are pathognomonic.
Labeled regions (3)
- 1Keratin pearl
Concentric whorl of keratinized cells — diagnostic for squamous differentiation.
- 2Intercellular bridges
Spiny processes between cells — desmosomes.
- 3Invasive nest
Irregular tumor island in stroma.
More pathology histology
Comedo DCIS — high-grade ductal carcinoma in situ
Breast
Liver cirrhosis — regenerative nodules + bridging fibrosis (Trichrome)
Liver
Cervical intraepithelial neoplasia (CIN 2 / HSIL)
Cervix
Acute MI — coagulative necrosis of cardiomyocytes
Heart (myocardium)
Adenocarcinoma — colon
Colon
Granulomatous inflammation — non-caseating (sarcoid pattern)