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Normal·Hematology/Immunology·Spleen

Spleen — white pulp + red pulp

Stain: H&E·Magnification: 10x·Tissue: Lymphoreticular·3 labeled regions
Spleen — white pulp + red pulp histology — Hematology/Immunology, Spleen, H&E
Wikimedia Commons · File:Spleen hyaloserositis - low mag.jpg · https://commons.wikimedia.org/wiki/File:Spleen_hyaloserositis_-_low_mag.jpg (CC-licensed)
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Description

White pulp = PALS (T cells) + B-cell follicles around central arterioles. Red pulp = cords of Billroth + sinusoids filtering blood.

Labeled regions (3)

  1. 1
    White pulp (PALS)

    Periarteriolar lymphoid sheath — T-cell zone.

  2. 2
    Central arteriole

    Sits within PALS — diagnostic feature.

  3. 3
    Red pulp / sinusoids

    Macrophages remove old RBCs; Howell-Jolly bodies appear in asplenia.

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Peripheral blood