Pathology

An elderly man has had several episodes in the past hematoma on the right. The most likely cause “for this few months of neurologic dysfunction with dysarthria, a finding is feeling of weakness in his hands, and dizziness, These ‘ , episodes usually last less than an hour, and then he feels (A) Tear of bridging veins i ‘ (B) Rupture of saccular aneurysm ’ fine again. However, he suddenly loses consciousness (C) Bleeding f arbuel ovenciis Taelfcnrae while walking to the bathroom in his house and falls to the = © ID} Laceration of the cnicdle misniogealerteey am floor, On regaining consciousness several minutes later, he 9° ch Teche 2 of vd ie adh Rent iekel is unable to move his right arm and he is unable to speak © en clearly. Which of the following pathologic findings in his 33, While worki : u i ing at her desk as an accountant, a 50brain would best explain these problems? year-old female experiences a sudden, severe headache, ln

A 43-year-old female has had a headache for a couthe hospital, she succumbed to pneumonia, At autopsy, the ple of weeks along with a fever, She has been healthy, — brain is atrophic, and the centrum semiovale and central except for a recent severe respiratory tract infection. A white matter are shrunken, gray, and translucent on gross head CT scan shows a sharply demarcated, 3-cm, ringexamination, Microscopically, there is widespread myelin enhancing lesion in the right occipital region, A lumbar — loss with sparing of subcortical U fibers, Which of the puncture is performed, and the CSF obtained shows a cell following degenerative CNS diseases is most likely to excount of 4 lymphocytes and 8 neutrophils, along with inplain her course? creased protein and normal glucose levels. The best diag- (A) Metachromatic leukodystrophy nosis 18 (B) Progressive multifocal leukoencephalopathy

A 62-year-old male has difficulty with voluntary movements because of muscular rigidity. He has an expressionless facies, When sitting, his hands have a “pill-rolling” tremor, Which of the following pathologic findings would best characterize his underlying disease condition?