Biochemistry

A newborn with ambiguous genitalia and a 46,XY karyotype develops vomiting, low serum sodium concentration, and high serum potassium. Which of the following proteins is most likely to be abnormal?

A child has ambiguous genitalia including an apparent small phallus and scrotum. The child’s DNA hybridizes to probes from the sex-determining region of the Y (SRY). Based on the clinical findings and dot-blot analysis, which of the following terms applies?

The dot-blot shown below examines DNA from a child with ambiguous genitalia after polymerase chain reaction (PCR) amplification and hybridization with DNA probes from the X and Y chromosome. In this case, the Y chromosome probe is from the SRY region of Yp that has recently been characterized as the male-determining region. DNA from control male and female patients is also applied to the dot-blot. Based on the dot-blot results, which is the most likely conclusion?