CNS Pharmacology

A 10-year-old boy was brought by his mother to their family physician’s o ce because she realized that recently the boy’s behavior had changed. Careful inquiry by the physician eventually made the boy admit he had started sni ng some paint thinners and stain removers, following a friend’s suggestion. The pattern of eeffects caused by these inhalants is most similar to that caused by which of the following drugs?

A 57-year-old homeless man was brought to the emergency department by the police, who had found him wandering the streets. The man had a long history of alcoholism; he also abused various inhalants when he did not have money to buy alcohol. He admitted that almost daily over the past 3 months, he had inhaled a drug supplied by a local vendor in cartridges because it was much cheaper than alcohol. Pertinent ndings on physical examination included muscle weakness, unsteady gait, vibratory sense loss on lower extremities, and hyperalgesia. Which of the following drugs most likely caused the patient’s syndrome?

A 55-year-old woman with a long history of severe alcoholism was admitted to the hospital because of deterioration of her general status. Physical examination and lab tests conrmed advanced liver cirrhosis. Which of the following was most likely another disease found in this patient?