Anti-inflammatory Pharmacology

A 45-year-old woman received a deceased-donor kidney transplant. Within 12 hours of the transplantation, she started immunosuppressive pharmacotherapy that included cyclosporine. Which of the following actions most likely mediated the therapeutic eeffect of the drug in the patient’s disease?

A 43-year-old man suffering from rheumatoid arthritis complained to his physician that his joint pain had increased recently despite current naproxen and hydroxychloroquine therapy. The patient was otherwise healthy, and his past medical history was unremarkable. Which of the following drugs would be appropriate to add to the patient’s therapy at this time?

A 44-year-old woman at a routine check-up was found to have a serum urate level of 18 mg/dL and a urine urate level of 800 mg/24 h. She started an appropriate treatment, and 3 weeks later her serum urate level was 7.2 mg/dL and urinary urate level was 530 mg/24 h. Which of the following drugs did the patient most likely take?